Taurolithocholic Acid-d5 Chemical Properties

storage temp. 

-20°C

solubility 

DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

A crystalline solid

CAS Number Unlabeled

6042-32-6

CAS Number Unlabeled

6042-32-6

Taurolithocholic Acid-d5 Usage And Synthesis

Description

Taurolithocholic acid-d4 (TLCA-d₄) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid .¹ TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.² It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.^3,4 Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.¹

Uses

Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

References

1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS) PLoS One 11(2),e0148869(2016).
2. Rust, C., Wild, N., Bernt, C., et al. Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent J. Biol. Chem. 284(5),2908-2916(2009).
3. Denk, G.U., Maitz, S., Wimmer, R., et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver Hepatology 52(5),1758-1768(2010).
4. Javitt, N.B. Cholestasis in rats induced by taurolithocholate Nature 210(5042),1262-1263(1966).

Taurolithocholic Acid-d5(2410279-97-7)Related Product Information

• 2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
• 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
• Tauroursodeoxycholic Acid-d4 (sodium salt)
• TAUROCHOLIC ACID-D4