Taurolithocholic Acid-d5
- Product Name
- Taurolithocholic Acid-d5
- CAS No.
- 2410279-97-7
- Chemical Name
- Taurolithocholic Acid-d5
- Synonyms
- Taurolithocholic acid-d4 sodium;D4-Taurolithocholic Acid Sodium Salt;Taurolithocholic acid, sodium salt (2,2,4,4-D?, 98%);TAUROLITHOCHOLICACID,SODIUMSALT(2,2,4,4-D4) IN METHANOL;Taurolithocholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol;2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
- CBNumber
- CB18570997
- Molecular Formula
- C26H46NNaO5S
- Formula Weight
- 507.71
- MOL File
- 2410279-97-7.mol
Taurolithocholic Acid-d5 Property
- storage temp.
- -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
- form
- A crystalline solid
- CAS Number Unlabeled
- 6042-32-6
Safety
- WGK Germany
- WGK 2
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
Taurolithocholic Acid-d5 Chemical Properties,Usage,Production
Description
Taurolithocholic acid-d4 (TLCA-d4) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid .1 TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.2 It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.3,4 Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1
Uses
Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
References
1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-
2. Rust, C., Wild, N., Bernt, C., et al. Bile acid-
3. Denk, G.U., Maitz, S., Wimmer, R., et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-
4. Javitt, N.B. Cholestasis in rats induced by taurolithocholate Nature 210(5042),1262-1263(1966).
Taurolithocholic Acid-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Taurolithocholic Acid-d5 Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 13540909846 13882008651
- 3848291069@qq.com
- Country
- China
- ProdList
- 3001
- Advantage
- 58
- Tel
- 021-64400900 15800436310
- bessey@reertech.com
- Country
- China
- ProdList
- 4105
- Advantage
- 58
- Tel
- 02151600108 13062666369
- info@isotopechem.com
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12064
- Advantage
- 58
- Tel
- 4008-099-669
- 23419001name@qq.com
- Country
- CHINA
- ProdList
- 6043
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58