Tauroursodeoxycholic Acid-d4 (sodium salt)
- Product Name
- Tauroursodeoxycholic Acid-d4 (sodium salt)
- CAS No.
- 2410279-95-5
- Chemical Name
- Tauroursodeoxycholic Acid-d4 (sodium salt)
- Synonyms
- D4-Tauroursodeoxycholic Acid Sodium Salt;Taurine ursodeoxycholic acid-d4 sodium salt;Tauroursodeoxycholic Acid-[d4] Sodium Salt in Methanol;Tauroursodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%);TAUROURSODEOXYCHOLICACID,SODIUMSALT(2,2,4,4-D4) IN METHANOL;Tauroursodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol;Tauroursodeoxycholic Acid-[d4] Sodium Salt/Tauroursodeoxycholic acid-[d4] sodium
- CBNumber
- CB88571049
- Molecular Formula
- C26H46NNaO6S
- Formula Weight
- 523.7
- MOL File
- 2410279-95-5.mol
Tauroursodeoxycholic Acid-d4 (sodium salt) Property
- storage temp.
- -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
- form
- A crystalline solid
- color
- White to off-white
- CAS Number Unlabeled
- 35807-85-3
Tauroursodeoxycholic Acid-d4 (sodium salt) Chemical Properties,Usage,Production
Description
Tauroursodeoxycholic acid-d4 (TUDCA-d4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .1,2 TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.2 It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.3,2
Uses
Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
References
1. Beuers, U. Effects of bile acids on hepatocellular signaling and secretion Yale J. Biol. Med. 70(4),341-346(1997).
2. Boatright, J.H., Nickerson, J.M., Moring, A.G., et al. Bile acids in treatment of ocular disease J. Ocul. Biol. Dis. Infor. 2(3),149-159(2009).
3. Vang, S., Longley, K., Steer, C.J., et al. The unexpected uses of urso-
Tauroursodeoxycholic Acid-d4 (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
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