2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
- Product Name
- 2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
- CAS No.
- 2410279-85-3
- Chemical Name
- 2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
- Synonyms
- Taurochenodeoxycholic acid-d4 Sodium;2H4]-Taurochenodeoxycholic Acid Sodium Salt;Taurine goose deoxycholic acid-d4 sodium salt;TAUROCHENODEOXYCHOLICACID,SODIUMSALT(2,2,4,4-D4) IN METHANOL;Taurochenodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%) CP 97%;Taurochenodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol, CP 97%;2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt;Ethanesulfonic acid, 2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-, sodium salt (1:1)
- CBNumber
- CB39082448
- Molecular Formula
- C26H41D4NO6S.Na
- Formula Weight
- 526.72
- MOL File
- 2410279-85-3.mol
2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 3 mg/ml
- form
- A solid
- CAS Number Unlabeled
- 6009-98-9
- CAS Number Unlabeled
- 6009-98-9
N-Bromosuccinimide Price
- Product number
- 21905
- Product name
- TaurochenodeoxycholicAcid-d4(sodiumsalt)
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>4</sub>)
- Packaging
- 500μg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 21905
- Product name
- TaurochenodeoxycholicAcid-d4(sodiumsalt)
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>4</sub>)
- Packaging
- 1mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 21905
- Product name
- TaurochenodeoxycholicAcid-d4(sodiumsalt)
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>4</sub>)
- Packaging
- 5mg
- Price
- $891
- Updated
- 2024/03/01
2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt Chemical Properties,Usage,Production
Uses
Taurochenodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
Biological Activity
Taurochenodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurochenodeoxycholic acid by GC- or LC-MS. TCDCA is a taurine-conjugated form of the primary bile acid chenodeoxycholic acid .1 Serum levels of TCDCA increase approximately 5-fold within two hours and begin to decrease within four hours during an oral lipid tolerance test in humans.2 Serum levels of TCDCA are increased in patients with liver cirrhosis and may serve as a marker of disease progression.3
References
1.Hoffman, A.F.The continuing importance of bile acids in liver and intestinal diseaseArch. Intern. Med.159(22)2647-2658(1999) 2.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 3.Wang, X., Xie, G., Zhao, A., et al.Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosisJ. Proteome Res.15(4)1126-1134(2016)
2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt Preparation Products And Raw materials
Raw materials
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