Sinomenine N-oxide Chemical Properties

Melting point:

155-156 °C(Solv: methanol (67-56-1))

pka

9.24±0.40(Predicted)

form 

Solid

color 

White to off-white

Sinomenine N-oxide Usage And Synthesis

Description

Sinomenine N-oxide is a plant extract with anti-angiogenic, anti-inflammatory and anti-rheumatic properties. It is also an inhibitor of NO production with an IC50 value of 23.04 μM.

Uses

Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].

References

[1] Liu WJ, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020 Jul 15;257:112871. DOI:10.1016/j.jep.2020.112871
[2] Zeng HL, et al. New N-oxide alkaloids from the stems of Sinomenium acutum. Fitoterapia. 2023 Mar;165:105404. DOI:10.1016/j.fitote.2022.105404
[3] Li Q, et al. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sci. 2020 Nov 15;261:118433. DOI:10.1016/j.lfs.2020.118433