dichlorisone Chemical Properties

Melting point:

238-241 °C (decomp)(Solv: acetone (67-64-1))

alpha 

D20 +134° (pyridine)

Boiling point:

586.4±50.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

solubility 

Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated)

form 

Solid

pka

11.99±0.70(Predicted)

color 

White to Off-White

dichlorisone Usage And Synthesis

Originator

Diloderm ,Schering,US,1960

Uses

Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

dichlorisone (7008-26-6)Related Product Information

• 1-Chlorotetradecane
• 6-Chloro-2-hexanone
• 1,10-Dichlorodecane
• 1,9-DICHLORONONANE
• 11-CHLORO-1-UNDECENE
• dichlorisone
• fluclorolone acetonide
• 3-CHLORO-2,2,3-TRIMETHYLBUTANE
• 10-CHLORO-1-DECANOL
• 6-CHLOROUNDECANE
• 9-CHLORO-2-METHYL-1-NONENE
• 7-Chloro-2-methylhept-1-ene
• 1-CHLORO-3,3-DIMETHYLPENTANE
• DICHLORISONE ACETATE
• 1,2-DICHLOROUNDECANE
• 1,2-DICHLOROTETRADECANE
• 1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-HEMISUCCINATE
• 1,2-DICHLOROTRIDECANE