α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4
α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4 Basic information
- Product Name:
- α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4
- Synonyms:
-
- α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4
- 3,4,4,4-D?, 98%)
- CAS:
- 1202865-40-4
- MF:
- C5H4D4O3.Na
- MW:
- 144.12
- Mol File:
- 1202865-40-4.mol
α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4 Chemical Properties
- CAS Number Unlabeled
- 3715-29-5
α-Keto Isovaleric Acid Sodium Salt 3-Methyl-13C, D4 Usage And Synthesis
Uses
Sodium 3-methyl-2-oxobutanoate-13C,d4 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate[1]. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[2][3][4].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93. DOI:10.1128/jb.65.4.388-393.1953
[3] Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr103(4):597-605. PMID:6366097
[4] Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9894(1):68-73. DOI:10.1016/s0006-8993(00)03321-7