2-Bromo-1,10-phenanthroline Chemical Properties

Melting point:

161.0 to 165.0 °C

Boiling point:

414.3±25.0 °C(Predicted)

Density 

1.616

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.20±0.10(Predicted)

form 

powder

color 

White to Light yellow to Light orange

InChI

InChI=1S/C12H7BrN2/c13-10-6-5-9-4-3-8-2-1-7-14-11(8)12(9)15-10/h1-7H

InChIKey

ZRJUDAZGVGIDLP-UHFFFAOYSA-N

SMILES

N1C2C(=CC=C3C=2N=CC=C3)C=CC=1Br

CAS DataBase Reference

22426-14-8

Safety Information

Risk Statements 

41

Safety Statements 

26-39

RIDADR 

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

HS Code 

29339900

2-Bromo-1,10-phenanthroline Usage And Synthesis

Uses

Brominated phenanthroline can be synthesized via a method reported by Baran and coworkers using a two-step protocol through N-Oxide formation using m-CBPA (Aldrich 273031) and bromination using TBAB (Sigma-Aldrich 426288) and p-Toluenesulfonic anhydride (Aldrich 259764).

Synthesis

The general procedure for the synthesis of 2-bromo-1,10-phenanthroline using 1-methyl-1,10-phenanthroline-2-one as starting material was as follows: phosphorus pentabromide (28 g; 65 mmol) and phosphorus tribromide oxide (50 g; 174 mmol) were added to 1-methyl-1,10-phenanthroline-2-one (10 g; 47.6 mmol) under the protection of argon gas at room temperature . The reaction system was warmed to 80 °C and the reaction mixture was stirred continuously for 6 hours. Upon completion of the reaction, the mixture was cooled in an ice bath and subsequently slowly poured into ice water. The pH of the mixture was adjusted to alkaline using concentrated ammonia. The reaction mixture was extracted using chloroform and the organic phase was collected and washed with water and subsequently dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (250 g of silica gel, eluent ratio of toluene/ethyl acetate = 5/1 to 3/1 to 1/1, and finally pure ethyl acetate) to give 6.9 g of the target product 2-bromo-1,10-phenanthroline in 94% yield. The product structure was confirmed by 1H NMR (CDCl3): δ 7.66 (dd, J1 = 8 Hz, J2 = 4.5 Hz, 1H), 7.76-7.79 (m, 2H), 7.83 (d, J = 8.5 Hz, 1H), 8.08 (d, J = 8.5 Hz, 1H), 8.26 (dd, J1 = 8 Hz, J2 = 2 Hz, 1H). 9.24 (dd, J1 = 4.5 Hz, J2 = 2 Hz, 1H). HPLC analytical conditions: mobile phase 20-90% acetonitrile-water (containing 0.1% trifluoroacetic acid), retention time of the target peaks was 4.2 min. ESIMS (positive ionization mode) m/z 260.9, 258.2 ([M + H]+, theoretical molecular weight of C12H7BrN2 259.1).

References

[1] Patent: WO2011/30566, 2011, A1. Location in patent: Page/Page column 25
[2] Patent: WO2012/124310, 2012, A1. Location in patent: Page/Page column 35-36
[3] Beilstein Journal of Organic Chemistry, 2012, vol. 8, p. 1037 - 1047

2-Bromo-1,10-phenanthroline(22426-14-8)Related Product Information

• 1,10-Phenanthrolin-5-amine
• 5-Nitro-1,10-phenanthroline
• 5-Bromo-1,10-phenanthroline Monohydrate
• 1,10-Phenanthroline-4-carboxylic acid
• 4-METHYL-1,10-PHENANTHROLINE
• 2-methyl-1,10-phenanthroline
• 5-METHYL-1,10-PHENANTHROLINE
• 5-CHLORO-1,10-PHENANTHROLINE
• Bathocuproine
• 1,10-Phenanthroline-4-carboxaldehyde
• Neocuproine
• 3,4,7,8-Tetramethyl-1,10-phenanthroline
• o-Phenanthroline
• 1,7-PHENANTHROLINE
• Bromine
• 2-Bromo-1,10-phenanthroline