5-Nitro-1,10-phenanthroline Chemical Properties

Melting point:

202-204 °C(lit.)

Boiling point:

366.71°C (rough estimate)

Density 

1.2844 (rough estimate)

refractive index 

1.5700 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Alcohol,Benzene

pka

pK1:3.232(+1) (25°C)

form 

crystalline

color 

yellow to orange

Water Solubility 

insoluble

BRN 

196245

CAS DataBase Reference

4199-88-6(CAS DataBase Reference)

EPA Substance Registry System

1,10-Phenanthroline, 5-nitro- (4199-88-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-40

Safety Statements 

26-36-24/25-22

WGK Germany 

3

TSCA 

Yes

HS Code 

29339900

MSDS

• Language:English Provider:Nitro-ferroin
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Nitro-1,10-phenanthroline Usage And Synthesis

Chemical Properties

Light yellow to yellow-brown crystalline powder

Uses

5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.

Biochem/physiol Actions

Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.

Purification Methods

Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]

5-Nitro-1,10-phenanthroline(4199-88-6)Related Product Information

• Ferrous sulfate heptahydrate
• 2-Nitrotoluene
• 3-Nitroacetophenone
• 2-Nitrobenzaldehyde
• 1,7-PHENANTHROLINE
• 3-METHYLADENINE
• 2-Nitrobenzoic acid
• 1-Fluoro-2-nitrobenzene
• 1,10-Phenanthroline hydrate
• 2-Nitrobenzyl alcohol
• 4-Nitrobenzoic acid
• o-Phenanthroline
• Nitroethane
• 2-Nitrochlorobenzene
• Nitromethane
• 4-Nitroaniline
• 2-Nitrophenol
• Nitrazepam