3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone Basic information
- Product Name:
- 3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone
- Synonyms:
-
- 3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone
- 1-[3-(5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4-yloxy)phenyl]ethanone
- WAY-357919
- Ethanone, 1-[3-[(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]phenyl]-
- VEGFR-2-IN-37
- 1-(3-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy)phenyl)ethan-1-one
- 1-(3-(5,6,7,8-4H-BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-4-YLOXY)-PHENYL)-ETHANONE
- CAS:
- 298207-77-9
- MF:
- C18H16N2O2S
- MW:
- 324.4
- Mol File:
- 298207-77-9.mol
More
Less
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone Chemical Properties
- Melting point:
- 148-149 °C
- Boiling point:
- 519.4±50.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- pka
- 2.07±0.20(Predicted)
- form
- Solid
- color
- Off-white to pink
More
Less
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone Usage And Synthesis
Uses
VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2. The inhibition rate at 200 μM was approximately 56.9 μM. VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation[1].
References
[1] Perspicace E, et al. Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). Eur J Med Chem. 2013 May;63:765-81. DOI:10.1016/j.ejmech.2013.03.022
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenoneSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
Shanghai Haohong Pharmaceutical Co., Ltd.
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
Jinan Jiuli Biotechnology Co. , Ltd.
- Tel
- 15865264761
- 486064515@qq.com
Bide Pharmatech Ltd.
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com