HYDROXYFASUDIL MONOHYDROCHLORIDE Chemical Properties

Melting point:

>250 (dec.)

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O: >5mg/mL

form 

solid

color 

white

Water Solubility 

Soluble in water (20mM)

InChIKey

XWWFOUVDVJGNNG-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HYDROXYFASUDIL MONOHYDROCHLORIDE Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.

General Description

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC₅₀ = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C

HYDROXYFASUDIL MONOHYDROCHLORIDE(155558-32-0)Related Product Information

• 5-Quinolinesulfonic acid, 2-methyl-
• Fasudil Pyridine N-Oxide TFA Salt
• 1,4-ditosyl-1,4-diazepane
• Fasudil diMer
• Fasudil Impurity 6
• Fasudil Impurity 13
• Fasudil N-hydroxy iMpurity
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• quinoline-5-sulphonic acid
• Fasudil Impurity
• 8-Methylquinoline
• 2-METHYLQUINOLINE-6-SULFONIC ACID
• Quinoline
• Fasudil IMpurity 3
• 1-(p-Toluenesulfonyl)hoMopiperazine, 95%
• Isoquinoline
• Fasudil Impurity 8
• N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE