1-Bromo-2-difluoromethoxy-4-fluoro-benzene Chemical Properties

Boiling point:

185.4±35.0 °C(Predicted)

Density 

1.660±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2909309090

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-bromo-2-(difluoromethoxy)-4-fluorobenzene from sodium difluorochloroacetate and 2-bromo-5-fluorophenol: 1. to a solution of 2-bromo-5-fluorophenol (3 g, 15.7 mmol) in DMF (5 ml) was added cesium carbonate (7.7 g, 23.56 mmol, 1.5 eq.) and sodium difluorochloroacetate (6 g, 39.26 mmol, 2.5 eq.). 2. The reaction mixture was heated and stirred at 100 °C for 15 hours. 3. After completion of the reaction, the reaction was terminated with water and ethyl acetate (3 x 50 ml). 4. The organic layer was separated, washed with water and brine, and then dried over anhydrous sodium sulfate. 5. The solvent was removed by pressurized distillation to obtain the crude product. 6. The crude product was purified by column chromatography (silica gel 60-120, eluent: 10% hexane solution of ethyl acetate) in 58% (2.2 g) yield.

References

[1] Patent: WO2014/162039, 2014, A1. Location in patent: Page/Page column 41
[2] Patent: EP2394987, 2011, A1. Location in patent: Page/Page column 9
[3] Patent: WO2012/143329, 2012, A1. Location in patent: Page/Page column 121

1-Bromo-2-difluoromethoxy-4-fluoro-benzene(954235-83-7)Related Product Information

• Cumene
• 3-(DIFLUOROMETHOXY)BROMOBENZENE
• 4-(DIFLUOROMETHOXY)BROMOBENZENE
• 4-Bromo-1-difluoromethoxy-2-fluoro-benzene
• 2-Bromo-5-fluoroanisole
• 1-Bromo-2-difluoromethoxy-4-fluoro-benzene