Asocainol
Asocainol Basic information
- Product Name:
- Asocainol
- Synonyms:
-
- Asocainol
- 6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)-5H-dibenz[d,f]azonin-1-ol
- Go-4704
- Goe-4704
- 5H-Dibenz[d,f]azonin-1-ol, 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)-
- CAS:
- 77400-65-8
- MF:
- C27H31NO3
- MW:
- 417.54
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Isotope Labelled Compounds
- Pharmaceuticals
- Mol File:
- 77400-65-8.mol
Asocainol Usage And Synthesis
Originator
Asocainol,ZYF Pharm
Uses
Asocainol (ASOC) belongs to class I antiarrhythmic drugs, i.e., those that exert their action at the level of sodium channels of the myocardial cell membrane.
Uses
Labelled Asocainol
Manufacturing Process
A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of 31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux for 2 hours, the reaction mixture is decomposed with a solution of 48 g ammonium chloride in 200 ml water. The usual working up, after conversion of the base into the hydrochloride by means of hydrogen chloride in ethyl acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7- methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride, melting point 227.6°C, after recrystallization from propan-2-ol.
Therapeutic Function
Antiarrhythmic
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