Darodipine
Darodipine Basic information
- Product Name:
- Darodipine
- Synonyms:
-
- Darodipine
- 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
- PY-108063
- PY-108068
- PY-108-068
- Darodipine(PY-108068)
- 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
- PY108068,Ca channels,PY 108068,Calcium Channel,Darodipine,Ca2+ channels,Inhibitor,inhibit
- CAS:
- 72803-02-2
- MF:
- C19H21N3O5
- MW:
- 371.39
- Mol File:
- 72803-02-2.mol
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Darodipine Chemical Properties
- Melting point:
- 148-151°C
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow to Light Yellow
- InChI
- InChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3
- InChIKey
- QERUYFVNIOLCHV-UHFFFAOYSA-N
- SMILES
- C1(C)NC(C)=C(C(OCC)=O)C(C2C3C(C=CC=2)=NON=3)C=1C(OCC)=O
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Darodipine Usage And Synthesis
Uses
Antihypertensive; bronchodilator; vasodilator.
Uses
Darodipine is a calcium channel antagonist.
in vivo
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine[1]. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex[2].
DarodipineSupplier
Zhengzhou Akem Chemical Co., Ltd Gold
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J & K SCIENTIFIC LTD.
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- 021-65675885 18964387627
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