Basic information Safety Supplier Related

Frentizole

Basic information Safety Supplier Related

Frentizole Basic information

Product Name:
Frentizole
Synonyms:
  • Frentizole
  • Frenazole
  • N-[6-Methoxybenzo[d]thiazol-2-yl]-N'-phenylurea
  • 1-(6-Methoxybenzothiazol-2-yl)-3-phenylurea
  • Lilly-53616
  • Urea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-
  • 1-(6-Methoxybenzo[d]thiazol-2-yl)-3-phenylurea
  • β-amyloid peptide,systemic lupus erythematosus,Aβ-ABAD,Inhibitor,rheumatoid arthritis,inhibit,Abeta,immunosuppressant,Amyloid-β,Frentizole
CAS:
26130-02-9
MF:
C15H13N3O2S
MW:
299.35
Mol File:
26130-02-9.mol
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Frentizole Chemical Properties

Density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 3 mg/mL (10.02 mM)
pka
7.02±0.70(Predicted)
form 
Powder
color 
White to off-white
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Frentizole Usage And Synthesis

Uses

Immunoregulator.

in vivo

Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice[2].

Animal Model:NZB/NZW mice[2]
Dosage:8.2 or 79.9 mg/kg/day for young mice
Administration:In animal feedings; 52 weeks
Result:Showed that the average lifespan of young untreated mice was 38 weeks, in the low dose group the average lifespan was about 38 weeks, and in the high dose group the lifespan was significantly longer with an average lifespan of about 61 weeks.
Significantly suppressed leukocyte counts, compared to a mean peripheral blood leukocyte count of 4160 in control mice, 3217 in low dose treated mice and 3450 in high dose treated mice.
Significant increased in terminal neutrophil counts in young low and high dose treated mice compared to control.

FrentizoleSupplier

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