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Sodium thioglycolate

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Sodium thioglycolate Basic information

Product Name:
Sodium thioglycolate
Synonyms:
  • NATG
  • SODIUM MERCAPTOACETATE
  • SODIUM THIOGLYCOLATE
  • SODIUM THIOGLYCOLLATE
  • THIOGLYCOLIC ACID SODIUM SALT
  • MERCAPTOACETIC ACID SODIUM SALT
  • Aceticacid,mercapto-,monosodiumsalt
  • Mercaptoaceticacidmonosodiumsalt
CAS:
367-51-1
MF:
C2H5NaO2S
MW:
116.11
EINECS:
206-696-4
Product Categories:
  • Flotation
  • 367-51-1
Mol File:
367-51-1.mol
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Sodium thioglycolate Chemical Properties

Melting point:
>300 °C (lit.)
vapor pressure 
<0.1 hPa (25 °C)
storage temp. 
-20°C
solubility 
609.1g/l
form 
solid
pka
3.82[at 20 ℃]
color 
White powder
Odor
Stench odour
PH Range
6.5 - 8 at 114 g/l at 25 °C
PH
6.7 (100g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,8692
BRN 
4569109
Exposure limits
ACGIH: TWA 1 ppm (Skin)
LogP
-2.99 at 20℃
CAS DataBase Reference
367-51-1(CAS DataBase Reference)
EPA Substance Registry System
Sodium thioglycolate (367-51-1)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-38-36/37/38
Safety Statements 
36-28-26
RIDADR 
2811
WGK Germany 
1
RTECS 
AI7700000
3-10-13-23
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29309070
Toxicity
LD50 i.p. in rats: 148 mg/kg, Freeman, Rosenthal, Fed. Proc. 11, 347 (1952)

MSDS

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Sodium thioglycolate Usage And Synthesis

Chemical Properties

White solid

Uses

dipilatory, irritant, chelating agent

Uses

Sodium thioglycolate has been used:

  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Uses

In cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid.

Definition

The sodium salt of thioglycolic acid.

General Description

White powder with a slight odor. Used in cold-waving of hair and as a dipilatory.

Air & Water Reactions

Hygroscopic. Discolors on exposure to air. Water soluble.

Reactivity Profile

Sodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.

Hazard

Yields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.

Fire Hazard

Flash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.

Purification Methods

It crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]

Sodium thioglycolateSupplier

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