Aminoquinuride Chemical Properties

Boiling point:

587.2±45.0 °C(Predicted)

Density 

1.423±0.06 g/cm3(Predicted)

pka

13.85±0.43(Predicted)

Aminoquinuride Usage And Synthesis

Uses

Surfen is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

IC 50

FGFR2: 5 μM (IC₅₀); HSV-1

References

[1] Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. DOI:10.1073/pnas.0805862105

Aminoquinuride(3811-56-1)Related Product Information

• Aminoquinuride
• 1,3-di-6-quinolylurea
• 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
• 4,6-DIAMINO-2-METHYL-QUINOLINE