1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

color 

Off-white to gray

1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Usage And Synthesis

Uses

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

IC 50

FGFR2: 5 μM (IC₅₀); HSV-1

storage

Store at -20°C

References

[1] Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. DOI:10.1073/pnas.0805862105

1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride(5424-37-3)Related Product Information

• 6-Aminoquinoline
• 4,6-DIAMINO-2-METHYL-QUINOLINE
• 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
• 1,3-di-6-quinolylurea
• Aminoquinuride
• 6-AMINOQUINOLINE HYDROCHLORIDE