Deracoxib Chemical Properties

Melting point:

159-161°

Boiling point:

575.5±60.0 °C(Predicted)

Density 

1.48

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), DMSO (Slightly)

pka

9.69±0.10(Predicted)

form 

Solid

color 

Light Brown

Deracoxib Usage And Synthesis

Uses

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Deracoxin is a selective cyclooxygenase-2 (COX-2) inhibitor used in the treatment of osteoarthritis in dogs. At low doses, adminsitartion of Deracoxin showed no factors associated with gastrointestinal tract perforation.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is us d in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.

Biological Activity

Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.

Veterinary Drugs and Treatments

Deracoxib is indicated for the treatment of post-operative pain (higher dose, 7 day maximum), and for the treatment of pain and inflammation associated with osteoarthritis (lower dose, ongoing dosing) in dogs.
Like piroxicam, deracoxib is of interest in adjunctive treatment of transitional cell carcinoma of the bladder; investigations into this use are ongoing.

Deracoxib(169590-41-4)Related Product Information

• Etoricoxib
• Valdecoxib
• 4-(3,5-DIMETHYL-PYRAZOL-1-YL)-BENZENESULFONAMIDE
• Deracoxib