Docarpamine Chemical Properties

Melting point:

85-90°; mp 105-108° (Nishiyama, 1992)

alpha 

D20 -15.6° (c = 2 in methanol)

Boiling point:

731.0±60.0 °C(Predicted)

Density 

1.222±0.06 g/cm3(Predicted)

pka

14.51±0.46(Predicted)

Safety Information

Toxicity

LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)

Docarpamine Usage And Synthesis

Description

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA₁) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Originator

Tanabe Seiyaku (Japan)

Uses

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Definition

ChEBI: Docarpamine is an organic molecular entity.

brand name

Tanadopa

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