Hopantenic Chemical Properties

Melting point:

62-64 °C

Boiling point:

556.0±50.0 °C(Predicted)

alpha 

D20 +23.8°

Density 

1.230±0.06 g/cm3(Predicted)

pka

4.52 at 25°

form 

Oil

color 

Colorless to light yellow

Safety Information

HazardClass 

IRRITANT

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 850, 954, 1575, 1458 i.p.; 2063, 2495, 5940, 7348 s.c.; 6297, 7935, 16810, 13350 orally (Nishizawa)

Hopantenic Usage And Synthesis

Uses

HoPan inhibits phosphopantotenoylcysteine synthetase activity.

Definition

ChEBI: Hopantenic acid is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

References

[1] Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414. DOI:10.1021/acschembio.1c00535

Hopantenic(18679-90-8)Related Product Information

• DIHYDRO-4,4-DIMETHYL-2,3-FURANDIONE
• Panthenol
• Dexpanthenol
• Dexpanthenol iMpurity F
• hopantenic acid
• L-Panthenol
• Hopantenic
• CALCIUM D-(+)-4-(2,4-DIHYDROXY-3,3-DIMETHYLBUTYLAMIDO)BUTYRATE HEMIHYDRATE