Meseclazone
Meseclazone Basic information
- Product Name:
- Meseclazone
- Synonyms:
-
- 3,3a-Dihydro-7-chloro-2-methyl-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one
- 7-Chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one
- W-2395
- NSC297623
- Meseclazone
- 7-chloro-2-methyl-3,3a-dihydro-2H-[1,2]oxazolo[3,2-b][1,3]benzoxazin-9-one
- 2H,9H-Isoxazolo[3,2-b][1,3]benzoxazin-9-one, 7-chloro-3,3a-dihydro-2-methyl-
- CAS:
- 29053-27-8
- MF:
- C11H10ClNO3
- MW:
- 239.65
- Mol File:
- 29053-27-8.mol
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Meseclazone Chemical Properties
- Melting point:
- 148°C
- Boiling point:
- 131.8°C (rough estimate)
- Density
- 1.3213 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- -3.18±0.40(Predicted)
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Meseclazone Usage And Synthesis
Uses
Anti-inflammatory.
in vivo
Meseclazone inhibits collagen-induced aggregation 1 and 4 hr after oral administration[1]. Intravenous administration of Meseclazone and other nonsteroidal anti-inflammatory drugs caused a dose-dependent inhibition of bronchoconstriction resulting in the following order of descending potency: isoproterenol congruent to indomethacin greater than fenoprofen greater than tolmetin greater than aspirin greater than naproxen congruent to ibuprofen greater than phenylbutazone greater than diflunisal greater than Meseclazone greater than 5-CSA[2].
MeseclazoneSupplier
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