Seclazone
Seclazone Basic information
- Product Name:
- Seclazone
- Synonyms:
-
- Seclazone
- W 2352
- W 2354
- W2354
- W-2354
- CAS:
- 29050-11-1
- MF:
- C10H8ClNO3
- MW:
- 225.63
- Mol File:
- 29050-11-1.mol
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Seclazone Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 14.29 mg/mL (63.33 mM)
- form
- Solid
- color
- Off-white to light yellow
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Seclazone Usage And Synthesis
Uses
Seclazone, a heterocyclic compound, possesses anti-inflammatory, analgesic, antipyretic and diuretic properties. Seclazone is orally active[1].
in vivo
Seclazone (220 mg/kg; p.o.; dietary, daily) inhibits the development of adjuvant-induced polyarthritis in rats[1].
Seclazone significantly lowers the fever induced in rats by administration of a yeast suspension[1].
| Animal Model: | Male Charles River rats (150-170 g) [1] |
| Dosage: | 220 mg/kg |
| Administration: | Oral administration, dietary, daily |
| Result: | Inhibited adjuvant-induced polyarthritis |
References
[1] F M Berger, et al. The pharmacological properties of seclazone (7-chloro-3,3a-dihydro-2H, 9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one) a new anti-inflammatory agent. Pharmacology. 1973;9(3):164-76. DOI:10.1159/000136381
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