Pipequaline Chemical Properties

Boiling point:

489.2±30.0 °C(Predicted)

Density 

1.078±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml

form 

A crystalline solid

pka

10.60±0.10(Predicted)

color 

White to off-white

Pipequaline Usage And Synthesis

Description

Pipequaline is a partial agonist of central benzodiazepine receptors (K_i = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil .

Pipequaline(77472-98-1)Related Product Information

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