Ethyl 7-chloro-2-oxoheptanoate Chemical Properties

Boiling point:

281.2±23.0 °C(Predicted)

Density 

1.093±0.06 g/cm3(Predicted)

refractive index 

1.4510 to 1.4560

storage temp. 

Inert atmosphere,2-8°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Liquid

color 

Clear Yellow

CAS DataBase Reference

78834-75-0(CAS DataBase Reference)

Safety Information

HS Code 

2918300090

Ethyl 7-chloro-2-oxoheptanoate Usage And Synthesis

Chemical Properties

Colorless to Light orange to Yellow clear liquid.

Uses

Ethyl 7-Chloro-2-oxoheptanoate is a reagent used in the synthesis of selective BCL-XL inhibitor A1155463 used in the treatment of cancer.

Uses

Ethyl 7-chloro-2-oxoheptanoate is a product of the Grignard reaction that can be used to synthesize organic compounds. It has been used in the preparation of pharmaceuticals such as cilastatin, which is used to inhibit cytochrome P450 enzymes in order to prolong the effectiveness of other drugs. This reagent also reacts with hydrochloric acid to form ethyl chloride and heptanoic acid, which can be used for chlorination reactions.

Preparation

Ethyl 7-chloro-2-oxoheptanoate is an organochlorine compound that is obtained by reacting ethyl chloride with magnesium in the presence of benzene and cilastatin as a catalyst.

Ethyl 7-chloro-2-oxoheptanoate(78834-75-0)Related Product Information

• Ethyl heptanoate
• Ethyl acrylate
• Epichlorohydrin
• Diethyl malonate
• Ethyl 2-chloroacetoacetate
• Ethyl cellulose
• Ethyl formate
• Ethanol
• Ethyl acetate
• Ethylparaben
• Ethyl chloroacetate
• 1-Bromo-5-chloropentane
• 1-Bromo-4-chlorobutane
• Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
• Cilastatin
• 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine