apogossypol
apogossypol Basic information
- Product Name:
- apogossypol
- Synonyms:
-
- apogossypol
- (+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol
- NSC736630
- APOGOSSYPOL;NSC736630
- 3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
- (+)-APOGOSSYPOL
- [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-
- (+)Apogossypol,(+) Apogossypol
- CAS:
- 66389-74-0
- MF:
- C28H30O6
- MW:
- 462.53
- Mol File:
- 66389-74-0.mol
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apogossypol Chemical Properties
- Melting point:
- 118-123 °C
- Boiling point:
- 673.3±50.0 °C(Predicted)
- Density
- 1.335±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- >16.2mg/mL in DMSO with gentle warming
- form
- Powder
- pka
- 8.03±0.50(Predicted)
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apogossypol Usage And Synthesis
Biological Activity
(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitro
In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivo
Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
target
| Mcl-1 < span> 2.6 μM (EC 50 ) | Bcl-2 2.8 μM (EC 50 ) | Bcl-xL 3.69 μM (EC 50 ) |
apogossypolSupplier
Chembest Research Laboratories Limited
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- 021-20908456
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Nanjing Peiwill Biotechnology Co.,Ltd.
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- 025-57027729 15850702895
- 15850702895@163.com
Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 18892239720
- psaitong@jm-bio.com
Musechem
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- +1-800-259-7612
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Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
- liming@bio-fount.com