squalamine
squalamine Basic information
- Product Name:
- squalamine
- Synonyms:
-
- (3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate
- MSI 1256
- Squalamine, >98%
- Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
- Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-
- CAS:
- 148717-90-2
- MF:
- C34H65N3O5S
- MW:
- 627.96
- EINECS:
- 202-303-5
- Mol File:
- 148717-90-2.mol
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squalamine Chemical Properties
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (159.25 mM)
- form
- Solid
- pka
- -3.49±0.18(Predicted)
- color
- Light yellow to yellow
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squalamine Usage And Synthesis
Uses
Squalamine is an aminosterol broad-spectrum antibacterial drug present in shark tissue.
Definition
ChEBI: Squalamine is a bile acid.
Biological Activity
Squalamine (MSI-1256) is a compound with broad-spectrum antiviral activity.
Synthesis
Squalamine is isolated from the stomach of spiny horn shark and sea green dog shark.
in vivo
Squalamine (2 mg/kg; Intraperitoneal injection; 28 days) inhibits tumor growth in xenografted mice with breast cancer[2].
Squalamine (20 mg; Single application; 0-3 days) has a decolonizing effect on S. aureus on the skin in a mouse model[3].
Squalamine (20-120 mg/kg; Oral gavage; 5 days) restores the function of the mesenteric nervous system in PD mouse models[4].
| Animal Model: | Female athymic mice aged 6 weeks old bearing breast tumor xenografts[2] |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); 28 days |
| Result: | Significantly retarded the growth of tumors, but the combination with Trastuzumab (HY-P9907) was more effective. Suppressed MCF-7/HER-2 breast xenograft-associated angiogenesis. |
| Animal Model: | 10 μL S. aureus suspension(108 cfu/mL) was applied to the female BALB/c mice skin[3] |
| Dosage: | 20 mg |
| Administration: | Single application; 3 days |
| Result: | Reduced S. aureus viable cells by up to 4 log after two days compared with the control. |
| Animal Model: | PD mice models ( hSNCAA53T mice and PrP-A53T human α-syn overexpressing transgenic mice)[4] |
| Dosage: | 20, 40, 80, or 120 mg/kg |
| Administration: | Oral gavage (i.g.); 5 days |
| Result: | Effectively restored disordered colonic motility in PD mice models. Increased colonic transit in PrP-A53T mice. Reduced myenteric intrinsic primary afferent neuron excitability in hSNCAA53T mice. |
squalamineSupplier
Artis Chemistry (Shanghai) Co. Ltd.
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- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Haoyuan Chemexpress Co., Ltd.
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LETOPHARM LIMITED
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