ascamycin
ascamycin Basic information
- Product Name:
- ascamycin
- Synonyms:
-
- ascamycin
- (+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine
- 2-Chloro-5'-O-[(L-alanylamino)sulfonyl]adenosine
- 2-Chloro-5'-O-[[(S)-2-amino-1-oxopropyl]sulfamoyl]adenosine
- CAS:
- 91432-48-3
- MW:
- 0
- Mol File:
- 91432-48-3.mol
ascamycin Usage And Synthesis
Biological Activity
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. It has selective antibacterial activity against Xanthomonas bacteria, with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
in vitro
The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface.
target
MIC: 0.4 μg/mL ( Xanthomonas citri ), 12.5 μg/mL ( Xanthomonas oryzae ) and 12.5 μg/mL ( Mycobacterium phlei )
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