4-methylhistamine Usage And Synthesis

Uses

4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2].

Definition

ChEBI: An aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring.

References

[1] Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. DOI:10.1016/j.imbio.2014.10.014
[2] Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17. DOI:10.1111/sji.12420

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