PD 123319 ditrifluoroacetate Chemical Properties

Boiling point:

775.8±60.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H₂O: 12 mg/mL

form 

powder

pka

2.80±0.20(Predicted)

Water Solubility 

Soluble to 100 mM in water

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

PD 123319 ditrifluoroacetate Usage And Synthesis

Uses

PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist.

Definition

ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively

Biological Activity

Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

References

[1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.
[2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.
[3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8.

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