vanicoside B
vanicoside B Basic information
- Product Name:
- vanicoside B
- Synonyms:
-
- vanicoside B
- α-D-Glucopyranoside, 1,3,6-tris-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl, 6-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate]
- CAS:
- 155179-21-8
- MF:
- C49H48O20
- MW:
- 956.89
- Mol File:
- 155179-21-8.mol
vanicoside B Chemical Properties
- Melting point:
- 157-159 °C
- Boiling point:
- 1165.0±65.0 °C(Predicted)
- Density
- 1.54±0.1 g/cm3(Predicted)
- pka
- 9.67±0.26(Predicted)
- form
- Solid
- color
- White to off-white
vanicoside B Usage And Synthesis
Uses
Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora. Vanicoside B targets cyclin-dependent kinase 8 (CDK8) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks CDK8-mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis[1][2].
in vivo
Vanicoside B (5 mg/kg and 20 mg/kg; i.p.; 3 times per week for 4 weeks) inhibits tumor growth in xenografted mouse models with MDAMB-231 cells[1].
| Animal Model: | MDA-MB-231 cell-implanted xenograft mouse model[1] |
| Dosage: | 5 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection; 3 times per week over 4 weeks |
| Result: | Significantly reduced tumor volumes at 5 mg/kg and 20 mg/kg by 53.85% and 65.72%, respectively. |
IC 50
CDK3; STAT3
References
[1] Kim D, et al. Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells. J Nat Prod. 2019 Nov 22;82(11):3140-3149. DOI:10.1021/acs.jnatprod.9b00720
[2] Takasaki M, et al. Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium. Cancer Lett. 2001 Nov 28;173(2):133-8. DOI:10.1016/s0304-3835(01)00670-x
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