Basic information Safety Supplier Related

QS 21

Basic information Safety Supplier Related

QS 21 Basic information

Product Name:
QS 21
Synonyms:
  • QS 21
  • QS-21 ADJUVANT
  • QA 21
  • QA 21V1
  • QS-21-Api
  • Saponin QA 21V1
  • CL130
  • β-D-Glucopyranosiduronic acid, (3β,4α,16α)-28-[[O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-O-[5-[[5-(α-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-β-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoole...
CAS:
141256-04-4
MF:
C92H148O46
MW:
1990.13
Mol File:
141256-04-4.mol
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QS 21 Chemical Properties

Density 
1.52±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C
pka
2.68±0.70(Predicted)
form 
Solid
color 
White to light yellow
InChIKey
CNEYUDLWGDOPIY-VWDQBTOUNA-N
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QS 21 Usage And Synthesis

Uses

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

in vivo

Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].

IC 50

NLRP3 inflammasome

References

[1] Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756. DOI:10.1021/acs.accounts.6b00242
[2] Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136 DOI:10.1074/jbc.M115.683011
[3] Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905. DOI:10.1016/j.phymed.2019.152905

QS 21Supplier

Hunan Furui Biopharma Technology Co., Ltd.
Tel
1822-2954721 15901640172
Email
sales03@hn-furui.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Email
aileen@chemfaces.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
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QS 21(141256-04-4)Related Product Information