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PHYLLANTHIN

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PHYLLANTHIN Basic information

Product Name:
PHYLLANTHIN
Synonyms:
  • PHYLLANTHIN
  • PHOSPHO-L-SERINE, O-(RG)
  • 1,1'-[(2S,3S)-2,3-Bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxybenzene]
  • NSC 619043
  • Phyllanthin (15 mg)
  • 3,3',4,4',9,9'-HexaMethoxylignan
  • Tetra-O-Methylsecoisolariciresinol
  • (2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane
CAS:
10351-88-9
MF:
C24H34O6
MW:
418.52
Mol File:
10351-88-9.mol
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PHYLLANTHIN Chemical Properties

Melting point:
96℃
Boiling point:
530.6±50.0 °C(Predicted)
Density 
1.069
storage temp. 
15-25°C
solubility 
DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form 
Solid
color 
White to off-white
BRN 
2066503
LogP
4.110 (est)
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Safety Information

WGK Germany 
3
HS Code 
3824999270
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PHYLLANTHIN Usage And Synthesis

Uses

Phyllanthin is a chemical extract from the Phyllanthus niruri plant and displays pharmacological effects as an anti-diabetic action, anti-arthritic, and inhibitor of P-gp.

Definition

ChEBI: Phyllanthin is a lignan.

in vivo

Phyllanthin (10 mg/kg; oral administration; once a day; 30 days) has protective effects in carbon tetrachloride (HY-Y0298) induced hepatotoxicity and experimental liver fibrosis in mice [2].
Phyllanthin (30 mg/kg; oral administration; single dose) exerts anti-tumor effects in diethylnitrosamine (HY-N7434) induced liver carcinogenesis in rats [5].
Phyllanthin (20-100 mg/kg; oral administration; once a day; 14 days) inhibits cellular and humoral immune responses in Balb/C mice [6].

Animal Model:Carbon tetrachloride (HY-Y0298) treated Swiss strain female mice (32-35 g) [2]
Dosage:10 mg/kg
Administration:Oral administration (p.o.); once a day; 30 days
Result:Normalized the level of liver marker enzymes (ALT and AST) and collagen content in hepatotoxicity and experimental liver fibrosis mice.
Restored normal liver architecture, reversed the formation of continuous fibrotic septa between the central and portal veins and nodules.
Reduced the levels of TGF-β1, ALK5, p-Smad2 and p-Smad3 in hepatotoxicity and experimental liver fibrosis mice.
Animal Model:Diethylnitrosamine (Cat. No. HY-N7434) treated male Wistar albino rats (210-230 g)[5]
Dosage:30 mg/kg
Administration:Oral administration (p.o.); single dose
Result:Significantly reduced 8-OHdG levels and delayed the oxidative damage in diethylnitrosamine -induced liver cancer rats.
Significantly reduced liver tissue injury biomarkers (ALT, AST, GGT, ALP and LDH) levels and tumor markers (AFP and CEA).
Reduced cellular enlargement, nodules, and hyperplasiaenlargement in diethylnitrosamine-induced liver tissue.
Animal Model:Male Balb/C mice aged 6-8 weeks old (18-22 g) [6]
Dosage:20 mg/kg, 40 mg/kg, and 100 mg/kg
Administration:Oral administration (p.o.); once a day; 14 days
Result:Dose-dependently inhibited CD11b/CD18 adhesion, the engulfment of E.coli by peritoneal macrophages molecules, NO and MPO release.
Dose-dependently inhibited T and B lymphocytes proliferation and down-regulated Th1 (IL-2 and IFN-γ) and Th2 (IL-4) cytokines.
Dose-dependently inhibited the sheep red blood cell (sRBC)-induced swelling rate of mice paw in delayed type hypersensitivity.
Significantly inhibited the serum levels of ceruloplasmin and lysozyme at higher doses (40 and 100 mg/kg).
Dose-dependently down-regulated anti-sRBC immunoglobulins (IgM and IgG) antibody titer.

PHYLLANTHINSupplier

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Chengdu Biopurify Phytochemicals Ltd.
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021-51320588
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