B-D-GLUCOPYRANOSE
B-D-GLUCOPYRANOSE Basic information
- Product Name:
- B-D-GLUCOPYRANOSE
- Synonyms:
-
- eraniin
- GERANIIN
- B-D-GLUCOPYRANOSE
- beta-D-Glucopyranose cyclic 2-7:4-5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-methano-2H-1-benzoxocin-5,7-dicarboxylate) cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate) stereoisomer
- 3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-pentaoxo-2,3,4,4a,9,11a,13,22,24,25,25a,27-dodecahydro-11H-3,5-epoxy-25,11-(epoxymethano)dibenzo[h,j]dibenzo[7,8:9,10][1,5]dioxacycloundecino[3,2-b][1,6]dioxacyclododecin-29-yl 3,4,5-trihydroxybenzoat
- 5-(3,6-dihydro-2,9,10,11,11-pentahydroxy-3-oxo-2,6-Methano-2H-1-benzoxocin-5,7-dicarboxylate)cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate)1-(3,4,5-trihydroxybenzoate), stereoisoMer
- 7:4®
- b-D-Glucopyranose, cyclic 2®
- CAS:
- 60976-49-0
- MF:
- C41H28O27
- MW:
- 952.64
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 60976-49-0.mol
B-D-GLUCOPYRANOSE Chemical Properties
- Density
- 2.25
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO : 100 mg/mL (104.97 mM; Need ultrasonic)
- form
- powder
- pka
- 6.35±0.70(Predicted)
- color
- Light yellow
B-D-GLUCOPYRANOSE Usage And Synthesis
Description
Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays. Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively). It inhibits angiotensin-converting enzyme (ACE) in vitro (IC50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells. It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.
Uses
Geraniin protects PC12 cells against neuronal damage and may be used in the treatment of Alzheimer’s disease/ Also is an ACE inhibitor which is useful for hypertension treatment.
Definition
ChEBI: Geraniin is a tannin.
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B-D-GLUCOPYRANOSE(60976-49-0)Related Product Information
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- alpha-D-Glucose pentaacetate
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- 2,3,4,6-TETRA-O-ACETYL-BETA-D-GLUCOPYRANOSE
- 3-O-METHYL-ALPHA-D-GLUCOPYRANOSE,3-O-METHYL-D-GLUCOPYRANOSE
- Streptozotocin
- 2-DEOXY-2-SULFAMINO-D-GLUCOPYRANOSE SODIUM SALT
- 2-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE
- 2-DEOXY-2-VALERAMIDO-D-GLUCOPYRANOSE,2-DEOXY-2-PENTANAMIDO-D-GLUCOPYRANOSE
- 3-O-METHYL-D-GLUCOPYRANOSE
- 2-DEOXY-2-HEXANAMIDO-D-GLUCOPYRANOSE
- 1,2,3,4,6-PENTA-O-ACETYL-A-GLUCOPYRANOSE
- DIETHYLENE GLYCOL MONO-METHACRYLATE
- 1,2,3,6-Tetra-O-benzyl-b-D-glucopyranoside
- BIPHENYL-2,2'-DICARBOXYLIC ACID DIMETHYL ESTER
- 2-(3-OXO-PROPYL)-BENZOIC ACID METHYL ESTER