Pasiniazid Chemical Properties

Melting point:

142-144°

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Water

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Pasiniazid Usage And Synthesis

Originator

Pasinazid, Yick-Vic Chemicals

Uses

antibacterial (tuberculostatic)

Uses

Pasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM).

Manufacturing Process

10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative

Therapeutic Function

Antitubercular

Pasiniazid(2066-89-9)Related Product Information

• antioxidant 1024
• Pyrazinamide
• Rifapentine
• Protionamide
• Rifampicin
• COD LIVER OIL
• Ketoconazole
• Isoniazid
• METHYL 4-AMINOSALICYLATE
• 4-Aminosalicylic acid
• 5-Aminosalicylic acid
• Sodium 4-aminosalicylate dihydrate
• Isonicotinic acid
• Isonicotinamide
• NICOTINIC ACID HYDRAZIDE
• PYRIDIN-4-YLMETHYL-HYDRAZINE
• Pasiniazid