Basic information Safety Supplier Related

Methylene boldenone

Basic information Safety Supplier Related

Methylene boldenone Basic information

Product Name:
Methylene boldenone
Synonyms:
  • METHYLENE BOLDENONE
  • (17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
  • Exemestane 17β-Hydroxy Impurity
  • (17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
  • 17--Hydroxy Exemestane
  • (17β)-
  • 17β-Hydroxy ExeMestane SulfaMate
  • Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
CAS:
122370-91-6
MF:
C20H26O2
MW:
298.42
Product Categories:
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids
Mol File:
122370-91-6.mol
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Methylene boldenone Chemical Properties

Melting point:
134-136°C
Density 
1.14
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White
CAS DataBase Reference
122370-91-6
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Methylene boldenone Usage And Synthesis

Description

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemical Properties

Off-White Solid

Uses

A metabolite of Exemestane; exerts biological effects as an androgen.

Uses

17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).

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