ISOVALERYL-L-CARNITINE CHLORIDE Chemical Properties

Melting point:

>160°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Methanol (Slightly), Water (Slightly, Heated)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

ISOVALERYL-L-CARNITINE CHLORIDE Usage And Synthesis

Description

Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).

Uses

Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.