ISOVALERYL-L-CARNITINE CHLORIDE Chemical Properties

Melting point:

>160°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Methanol (Slightly), Water (Slightly, Heated)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

CAS Number Unlabeled

139144-12-0

ISOVALERYL-L-CARNITINE CHLORIDE Usage And Synthesis

Description

Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).

Uses

Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.

IC 50

Human Endogenous Metabolite

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ROBERTO PAOLO REVOLTELLA . l-Carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et biophysica acta. Molecular cell research, 1994, 1224 3: Pages 333-341. DOI: 10.1016/0167-4889(94)90265-8
[3] G MIOTTO. Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.[J]. The Journal of Biological Chemistry, 1992, 267 31: 22066-22072.
[4] PIERO RINALDO  Dietrich M  Tina M Cowan. Acylcarnitine profile analysis[J]. Genetics in Medicine, 2008, 10 2: Pages 151-156. DOI: 10.1097/gim.0b013e3181614289