1-(6-nitropyridin-3-yl)piperazine Chemical Properties

Boiling point:

422.8±40.0 °C(Predicted)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform; Methanol

form 

Solid

pka

8.50±0.10(Predicted)

color 

Yellow

1-(6-nitropyridin-3-yl)piperazine Usage And Synthesis

Uses

1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

1-(6-nitropyridin-3-yl)piperazine(775288-71-6)Related Product Information

• tert-butyl 4-(4-aminopyridin-2-yl)piperazine-1-carboxylate
• 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
• 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Palbociclib Impurity 61
• 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
• INDEX NAME NOT YET ASSIGNED
• 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
• 2324831-15-2
• 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
• 5-(piperazin-1-yl)pyridin-2-aMine
• Palbociclib Impurity V
• tert-butyl 4-(3-nitropyridin-4-yl)piperazine-1-carboxylate
• 4-(6-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• 1-BOC-4-(3-AMINO-4-PYRIDINYL)-PIPERAZINE
• 1-(6-AMino-2,3-diMethoxy-phenyl)-ethanone
• Palbociclib Impurity 59
• 1-(3-Pyridinyl)piperazine