N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Chemical Properties

Melting point:

>200 °C (sublm)(Solv: ethanol (64-17-5))

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

color 

White

InChI

InChI=1S/C3H6F3N.ClH/c1-7-2-3(4,5)6;/h7H,2H2,1H3;1H

InChIKey

CUOWKFXFKFXJEL-UHFFFAOYSA-N

SMILES

C(CNC)(F)(F)F.[H]Cl

Safety Information

HazardClass 

IRRITANT

HS Code 

2921199990

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Usage And Synthesis

Synthesis

General procedure for the synthesis of N-methyl-2,2,2-trifluoroacetamide hydrochloride from N-methyl-2,2,2-trifluoroacetamide: A solution was prepared by dissolving lithium aluminum hydride (69 g, 1.8 mol) in 100 mL of ether at 100 °C. To this solution, an ether solution of 2,2,2-trifluoro-N-methylacetamide (86 g, 0.6 mol) was slowly added at 0 °C. The reaction mixture was stirred at room temperature overnight. Subsequently, sodium sulfate decahydrate was added to the mixture at -10°C and the resulting suspension was filtered. Dry HCl gas was passed into the filtrate until a white solid precipitated. The solid product was separated by filtration and recrystallized with a solvent mixture of methanol/ether to give N-methyl-2,2,2-trifluoroethylamine hydrochloride as a final white solid (73 g, 80.7% yield).

References

[1] Patent: WO2010/131145, 2010, A1. Location in patent: Page/Page column 76

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