DODECANEDIOIC ACID MONOMETHYL ESTER Chemical Properties

Melting point:

51.5-52 °C

Boiling point:

170 °C(Press: 3 Torr)

Density 

1.012±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly)

form 

Solid

pka

4.78±0.10(Predicted)

color 

White

InChI

InChI=1S/C13H24O4/c1-17-13(16)11-9-7-5-3-2-4-6-8-10-12(14)15/h2-11H2,1H3,(H,14,15)

InChIKey

REGGDLIBDASKGE-UHFFFAOYSA-N

SMILES

C(OC)(=O)CCCCCCCCCCC(O)=O

Safety Information

HS Code 

2917198090

DODECANEDIOIC ACID MONOMETHYL ESTER Usage And Synthesis

Chemical Properties

White Solid

Uses

Used in cosmetic compositions.

Uses

Dodecanedioic Acid 1-Methyl Ester is used in cosmetic composition.

Synthesis

Synthesis of compound 2: To a stirred solution of dimethyl dodecanedioate 1 (200 g, 774.65 mmol) in a mixed solvent of diethyl ether and acetonitrile, potassium hydroxide (891.4 mmol) dissolved in methanol was slowly added, keeping the reaction temperature between 0-5°C for 1 hour. Subsequently, the reaction mixture was continued to be stirred at the same temperature for 48 hours. Upon completion of the reaction, the white solid in the reaction mixture was filtered using a sintered funnel and washed with diethyl ether (100 mL) followed by suction drying for 3 hours. The resulting white solid was dissolved in water (500 mL), acidified to pH 3-4 with 1N hydrochloric acid solution, filtered to collect the precipitated white solid and washed with water (50 mL x 2). Finally, the product was air-dried in air for 1 day and then dried in the presence of phosphorus pentoxide to give monomethyl dodecanedioate 2 (166 g, 88% yield) as a white powder.

References

[1] Patent: WO2014/25805, 2014, A1. Location in patent: Page/Page column 33
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 16, p. 4253 - 4256
[3] Chemische Berichte, 1983, vol. 116, # 2, p. 761 - 776
[4] Helvetica Chimica Acta, 2005, vol. 88, # 9, p. 2470 - 2478
[5] Synthesis, 2010, # 7, p. 1150 - 1158

DODECANEDIOIC ACID MONOMETHYL ESTER(3903-40-0)Related Product Information

• TRIETHANOLAMMONIUM DODECYLBENZENE SULFONATE
• Sodium dodecylbenzenesulphonate
• Disodium 4-dodecyl-2,4'-oxydibenzenesulfonate
• dodecylbenzenesulphonic acid, compound with isopropylamine (1:1)
• dodecylbis(2-hydroxyethyl)methylammonium chloride
• DODECYLBENZENE SODIUM SULFONATE
• Dodecyldimethylbenzylammonium chloride
• SODIUM DODECYL DIPHENYL ETHER DISULFONATE
• 1,2-Dodecanediol
• 1-Dodecylpyridinium chloride
• 1-Dodecylpyridinium bromide
• DODECYL METHYL SULFOXIDE
• POLY(ETHYLENE-ALT-MALEIC ANHYDRIDE)
• STYRENE MALEIC ANHYDRIDE COPOLYMER
• POLY(MALEIC ANHYDRIDE-ALT-1-OCTADECENE)
• Dimethyl dodecanedioate
• Dodecane
• Dodecanedioic acid