D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Chemical Properties

Boiling point:

555.6±60.0 °C(Predicted)

Density 

1.449±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

form 

Powder

pka

1.27±0.10(Predicted)

color 

White

Water Solubility 

Soluble to 100 mM in water

D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Usage And Synthesis

Uses

D-CPP-ene is a potent, competitive NMDA antagonist (1). NMDA antagonists such as this may increase sucrose intake through hunger satiation delay (2).

Definition

ChEBI: Midafotel is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). It has a role as a NMDA receptor antagonist, a neuroprotective agent and an anticonvulsant. It is a piperazinecarboxylic acid, a monocarboxylic acid, a member of phosphonic acids, an olefinic compound and a tertiary amino compound.

Biological Activity

Potent and competitive NMDA antagonist (K i = 40 nM). Centrally active following systemic administration.

storage

Room temperature

D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID(117414-74-1)Related Product Information

• [2R,(-)]-4-(3-Phosphono-2-propenyl)-2-piperazinecarboxylic acid
• 2-Piperazinecarboxaldehyde
• PIPERAZINE-2-CARBOXYLIC ACID
• 3-(N,N-Dimethylamino)-D-alanine
• D-SS-(N-METHYLAMINO)ALANINE
• D-2,3-Diaminopropionic acid
• 4-METHYLPIPERAZINE-2-CARBOXYLIC ACID
• (R)-PIPERAZINE-2-CARBOXYLIC ACID
• D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
• 3-(N,N-Diethylamino)-L-alanine