2',6'-DIMETHYLACETANILIDE Chemical Properties

Melting point:

182-184 °C(lit.)

Boiling point:

290.31°C (rough estimate)

Density 

1.052

refractive index 

1.5400 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

15.14±0.70(Predicted)

color 

Crystals

CAS DataBase Reference

2198-53-0(CAS DataBase Reference)

EPA Substance Registry System

Acetamide, N-(2,6-dimethylphenyl)- (2198-53-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

AN7470000

TSCA 

Yes

HS Code 

29242990

Toxicity

LD50 orl-mus: 620 mg/kg TXAPA9 19,20,71

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2',6'-DIMETHYLACETANILIDE Usage And Synthesis

Chemical Properties

off-white to yellow cryst. needles or cryst.powder

Uses

Lidocaine (L397800) impurity.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Chemical and Pharmaceutical Bulletin, 30, p. 4242, 1982 DOI: 10.1248/cpb.30.4242
Journal of Heterocyclic Chemistry, 2, p. 181, 1965 DOI: 10.1002/jhet.5570020214

General Description

2,6-Dimethylacetanilide undergoes iodination by electrophylic substitution reaction of chloroacetanilide, in the presence of ferroiodide and copperchloride as catalyst, to form 4-iodine-2,6-dimethylacetanilide.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofNOx.

2',6'-DIMETHYLACETANILIDE(2198-53-0)Related Product Information

• 2',6'-DIMETHYLACETANILIDE
• 2-Chloro-N-(2,6-dimethylphenyl)acetamide
• Lidocaine
• 2,4-DIMETHYLACETANILIDE,2',4'-DIMETHYLACETANILIDE
• 3,4-DIMETHYLACETANILIDE 98+%,3',4'-DIMETHYLACETANILIDE,3,4-DIMETHYLACETANILIDE
• Ranolazine
• α-Chloro-N-(2-methoxyethyl)-2',6'-dimethylacetanilide
• N-(2,5-diMethylphenyl)acetaMide
• 2-Acetyl-2',4'-dimethylacetanilide
• 2-chloro-N-(3-methoxy-2-thienyl-2′,6′-dimethylacetanilide
• A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE HYDROCHLORIDE
• 2-Bromo-2',6'-dimethylacetanilide
• 1-(2,6-DIMETHYL-PHENYL)-PYRROLE-2,5-DIONE
• 6-BROMO-4-METHYL-1-PHENYLANTHRAPYRIDONE
• AURORA 10634
• N-(2,6-dimethylphenyl)-3-oxobutanamide
• TIMTEC-BB SBB005915
• 4-[(2,6-DIMETHYLPHENYL)AMINO]-4-OXOBUTANOIC ACID