DNP-PRO-BETA-CYCLOHEXYL-ALA-ABU-CYS(ME)-HIS-ALA-LYS(N-ME-ABZ)-NH2 Chemical Properties

storage temp. 

-15°C

Sequence

{DNP}-Pro-Cha-Abu-{Cys(Me)}-His-Ala-Lys(N-Me-Abz)-NH2

DNP-PRO-BETA-CYCLOHEXYL-ALA-ABU-CYS(ME)-HIS-ALA-LYS(N-ME-ABZ)-NH2 Usage And Synthesis

Description

Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. It is cleaved by MMP-1 and MMP-9 to release N-methylanthranilic acid (Nma), which is unquenched and its fluorescence can be used to quantify MMP activity.

Uses

MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity[1].

References

[1] Kumar JD, et al. Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G78-86. DOI:10.1152/ajpgi.00084.2015

Sequene

Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(Nma)-NH2

DNP-PRO-BETA-CYCLOHEXYL-ALA-ABU-CYS(ME)-HIS-ALA-LYS(N-ME-ABZ)-NH2(150956-93-7)Related Product Information

• 2,4-Dinitrophenylhydrazine
• 2-PYRROLIDIN-1-YLANILINE 97
• MMP-1/MMP-9 SUBSTRATE, FLUOROGENIC
• 1-(2-NITRO-PHENYL)-PYRROLIDINE
• N1-(2,4-DINITRO-PHENYL)-ETHANE-1,2-DIAMINE
• L-PROLINE N-OCTYLAMIDE
• 3-CYCLOHEXYL-L-ALANINE AMIDE
• 2-amino-n-butyl-benzamide
• DNP-PRO-BETA-CYCLOHEXYL-ALA-ABU-CYS(ME)-HIS-ALA-LYS(N-ME-ABZ)-NH2
• 2,4-DINITRO-N,N-DIETHYLANILINE
• 2-METHYL-1-PHENYL-PYRROLIDINE