MMP-1/MMP-9 SUBSTRATE, FLUOROGENIC Chemical Properties

Boiling point:

1490.5±65.0 °C(Predicted)

Density 

1.341±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Formic Acid: 1 mg/ml

form 

A lyophilized powder

pka

12.81±0.46(Predicted)

Sequence

{Dnp}-Pro-{Cha}-Gly-{Cys(Me)}-His-Ala-{Lys(Nma)}-NH2

MMP-1/MMP-9 SUBSTRATE, FLUOROGENIC Usage And Synthesis

Description

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH₂ is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

Uses

MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9[1].Ex/Em = 340/440 nm

References

[1] B T Frank, et al. Mast Cell Tissue Inhibitor of Metalloproteinase-1 Is Cleaved and Inactivated Extracellularly by α-Chymase. J Immunol.2001 Feb 15;166(4):2783-92. DOI:10.4049/jimmunol.166.4.2783

Sequene

Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Nma)-NH2

MMP-1/MMP-9 SUBSTRATE, FLUOROGENIC(150956-92-6)Related Product Information

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