AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT Chemical Properties

storage temp. 

Store at -20°C

solubility 

Water: 0.3 mg/ml

form 

A powder

AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT Usage And Synthesis

Description

Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin. It is a somatostatin (SST) receptor agonist that binds to SST₁, SST₂, SST₃, SST₄, and SST₅ (IC₅₀s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant receptors). It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST₁, SST₂, SST₃, SST₄, and SST₅ (EC₅₀s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively). Somatostatin-14 inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules.

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