ARGIPRESSIN ACETATE Chemical Properties

Melting point:

189 °C(dec.)

storage temp. 

−20°C

solubility 

Water: 1 mg/ml

form 

powder to crystal

color 

White to Light yellow

Water Solubility 

Water: 1 mg/ml

Safety Information

Hazard Codes 

Xn

Risk Statements 

20

Safety Statements 

36

WGK Germany 

3

F 

3-10

HS Code 

2937.19.0000

MSDS

• Language:English Provider:SigmaAldrich

ARGIPRESSIN ACETATE Usage And Synthesis

Description

Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V₁, with K_d values of 1.31 and 1.44 nM in A₇r₅ rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively. It also stimulates the intracellular release of calcium in A₇r₅ cells (EC₅₀ = 5 nM). In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.

Uses

Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1[1][2][3][4].

in vivo

References

[1] Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie. DOI:10.1016/j.biochi.2019.01.008
[2] Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. DOI:10.1210/endo-129-6-2845
[3] Moriya T, et al. Vasopressin-induced intracellular Ca2? concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. DOI:10.1016/j.brainres.2012.08.028
[4] Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. DOI:10.4097/kjae.2017.70.3.245

ARGIPRESSIN ACETATE(129979-57-3)Related Product Information

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