1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Chemical Properties

Melting point:

75-79 °C

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder

color 

white to off-white

Stability:

Moisture Sensitive

InChIKey

HVAPLSNCVYXFDQ-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37

RIDADR 

1325

WGK Germany 

3

TSCA 

No

HazardClass 

4.1

PackingGroup 

Ⅲ

HS Code 

29349990

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Usage And Synthesis

Description

1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.

Reference

J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682

Chemical Properties

White to light yellow solid

Uses

Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates.

Uses

Togni’s Reagent is used in trifluoromethylation reactions.

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent(887144-97-0)Related Product Information

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• 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one
• (PERFLUORO-N-HEXYL)PHENYLIODONIUM TRIFLUOROMETHANESULFONATE
• Pyrazine
• Lactic acid
• N,N-Dimethylacetamide
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• Diphenyl(trifluoromethyl)sulfonium trifluoromethanesulfonate
• 2,2,2-trifluoroethyl(phenyl)iodonium trifluoromethanesulfonate
• diphenyl(2,2,2-trifluoroethyl)sulfanium trifluoromethanesulfonate
• (perfluoroethyl)diphenylsulfonium trifluoromethanesulfonate
• Mesityl(2,2,2-trifluoroethyl)iodonium trifluoromethanesulfonate
• (difluoromethyl)(2,4-dimethylphenyl)(phenyl)sulfonium tetrafluoroborate
• Iodonium, (1,1,2,2,3,3,4,4,4-nonafluorobutyl)phenyl-,1,1,1-trifluoromethanesulfonate
• (2,2-difluoroethyl)diphenylsulfonium trifluoromethanesulfonate
• 2-IODOISOPROPYLBENZENE
• Trifluoromethyl iodide
• 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent