1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

Description Reference

Product Name: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
CAS No.: 887144-97-0
Chemical Name: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
Synonyms: Togni Reagent;3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole;1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole;togni's reagent;togni's reagent;3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole;3,3-Dimethyl-1-(trifluoromethyl)-1,2-benzodioxole;1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b;1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-;3,3-dimethyl-1-(trifluoromethyl)-1λ3,2-benziodoxole
CBNumber: CB22101080
Molecular Formula: C10H10F3IO
Formula Weight: 330.09
MOL File: 887144-97-0.mol

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Property

Melting point:: 75-79 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder
color: white to off-white
Stability:: Moisture Sensitive
InChI: InChI=1S/C10H10F3IO/c1-9(2)7-5-3-4-6-8(7)14(15-9)10(11,12)13/h3-6H,1-2H3
InChIKey: HVAPLSNCVYXFDQ-UHFFFAOYSA-N
SMILES: I1(C(F)(F)F)C2=CC=CC=C2C(C)(C)O1

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
RIDADR: 1325
WGK Germany: 3
TSCA: No
HazardClass: 4.1
PackingGroup: Ⅲ
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 1g
Price: $456
Updated: 2025/07/31

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 5g
Price: $881
Updated: 2025/07/31

TCI Chemical

Product number: T2624
Product name: 1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $210
Updated: 2025/07/31

TCI Chemical

Product number: T2624
Product name: 1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $729
Updated: 2025/07/31

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 250mg
Price: $123
Updated: 2025/07/31

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Chemical Properties,Usage,Production

Description

1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.

Reference

J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682

Chemical Properties

White to light yellow solid

Uses

Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates.

Uses

Togni’s Reagent is used in trifluoromethylation reactions.

reaction suitability

reaction type: C-C Bond Formation

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Suppliers

China 153 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 12 Global 173

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

Shanghai Silan Pharmaceutical Technology Co. , Ltd.

Tel: 17301772648
Email: 3153252124@qq.com
Country: China
ProdList: 401
Advantage: 58

Yangzhou modier Electronic Materials Co., Ltd

Tel: 0514-82098883; 13761402923
Email: market@modeltemol.com
Country: China
ProdList: 993
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Togni's Reagent 887144-97-0
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent 887144-97-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Shaanxi Dideu New Materials Co. Ltd

Product: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent 887144-97-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-28

887144-97-0, 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis ReagentRelated Search:

(Difluoromethyl)bis(2,5-dimethylphenyl)sulfonium Tetrafluoroborate 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one (PERFLUORO-N-HEXYL)PHENYLIODONIUM TRIFLUOROMETHANESULFONATE Pyrazine Lactic acid N,N-Dimethylacetamide N,N-Dimethylaniline Diphenyl(trifluoromethyl)sulfonium trifluoromethanesulfonate 2,2,2-trifluoroethyl(phenyl)iodonium trifluoromethanesulfonate diphenyl(2,2,2-trifluoroethyl)sulfanium trifluoromethanesulfonate (perfluoroethyl)diphenylsulfonium trifluoromethanesulfonate Mesityl(2,2,2-trifluoroethyl)iodonium trifluoromethanesulfonate (difluoromethyl)(2,4-dimethylphenyl)(phenyl)sulfonium tetrafluoroborate Iodonium, (1,1,2,2,3,3,4,4,4-nonafluorobutyl)phenyl-,1,1,1-trifluoromethanesulfonate (2,2-difluoroethyl)diphenylsulfonium trifluoromethanesulfonate 2-IODOISOPROPYLBENZENE Trifluoromethyl iodide 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole

1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole

1,3-dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

1,3-Dhydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b

3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole 95%

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole / TOGNI A

1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-

Togni Reagent

3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole (Togni‘s reagent)

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, >=98%

3,3-Dimethyl-1-(trifluoromethyl)-1,2- benziodoxole (Togni's reagent I)

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benzodioxole

1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole, 97%, for synthesis

3,3-dimethyl-1-(trifluoromethyl)-1$l^{3},2-benziodoxole

3,3-dimethyl-1-(trifluoromethyl)-1λ3,2-benziodoxole

Togni`s Reagent (3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole) extrapure, 97%

togni's reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (ACI)

togni's reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole - [D52498]

887144-97-0

C10H10F3IO