4'-Hydroxyphenyl Carvedilol Chemical Properties

Melting point:

163-165°C

Boiling point:

702.0±60.0 °C(Predicted)

Density 

1.305±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.94±0.20(Predicted)

color 

White to Light Brown

Safety Information

HS Code 

9999999999

4'-Hydroxyphenyl Carvedilol Usage And Synthesis

Description

4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.

Chemical Properties

Off-White Solid

Uses

A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.

Uses

4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.

Uses

An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.

Definition

ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.

References

[1] DAXESH P. PATEL. UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers[J]. Biomedical Chromatography, 2013, 27 8: 974-986. DOI: 10.1002/bmc.2889
[2] H G OLDHAM  S E C. In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.[J]. Drug Metabolism and Disposition, 1997, 25 8: 970-977.
[3] THOMAS C MALIG. Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolites.[J]. MedChemComm, 2017: 606-615. DOI: 10.1039/c7md00014f

4'-Hydroxyphenyl Carvedilol(142227-49-4)Related Product Information

• SB 209995
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• 4'-HYDROXYPHENYL CARVEDILOL
• 5'-HYDROXYPHENYL CARVEDILOL
• (S)-(-)-5'-HYDROXYPHENYL-CARVEDILOL
• (R)-(+)-5'-HYDROXYPHENYL CARVEDILOL
• 4'-HYDROXYPHENYL CARVEDILOL-D5
• (S)-(-)-4'-BENZYLOXYPHENYLOXY-CARVEDILOL
• 4'-HYDROXYPHENYLCARVEDILOL-D3
• 4'-BENZYLOXY-CARVEDILOL
• (R)-(+)-4'-BENZYLOXY-CARVEDILOL
• 4'-Hydroxyphenyl Carvedilol