4'-Hydroxyphenyl Carvedilol Chemical Properties

Melting point:

163-165°C

Boiling point:

702.0±60.0 °C(Predicted)

Density 

1.305±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.94±0.20(Predicted)

color 

White to Light Brown

Safety Information

HS Code 

9999999999

4'-Hydroxyphenyl Carvedilol Usage And Synthesis

Description

4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.

Chemical Properties

Off-White Solid

Uses

A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.

Uses

4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.

Uses

An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.

Definition

ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.

4'-Hydroxyphenyl Carvedilol(142227-49-4)Related Product Information

• SB 209995
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• 4'-HYDROXYPHENYL CARVEDILOL
• 5'-HYDROXYPHENYL CARVEDILOL
• (S)-(-)-5'-HYDROXYPHENYL-CARVEDILOL
• (R)-(+)-5'-HYDROXYPHENYL CARVEDILOL
• 4'-HYDROXYPHENYL CARVEDILOL-D5
• (S)-(-)-4'-BENZYLOXYPHENYLOXY-CARVEDILOL
• 4'-HYDROXYPHENYLCARVEDILOL-D3
• 4'-BENZYLOXY-CARVEDILOL
• (R)-(+)-4'-BENZYLOXY-CARVEDILOL
• 4'-Hydroxyphenyl Carvedilol