6,6'-Dichloro-2,2'-bipyridine Chemical Properties

Melting point:

220℃ (benzene )

Boiling point:

354.7±37.0 °C(Predicted)

Density 

1.363±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Inert atmosphere,Room Temperature

pka

-0.40±0.10(Predicted)

Appearance

Off-white to pink Solid

6,6'-Dichloro-2,2'-bipyridine Usage And Synthesis

Synthesis

The synthesis of 6,6'-dichloro-2,2'-bipyridine (52a) was achieved by reacting a mixture of BuLi/Me2N(CH2)2OLi with 2-chloropyridine as starting material. This mixture served as a base for selective lithiation of the C-6 region (Scheme 23). The 6-lithium-2-chloropyridine generated during the reaction was further reacted with the starting material 2-chloropyridine to produce the target coupling product 52a in 47% yield.

References

[1] Organic Letters, 2000, vol. 2, # 6, p. 803 - 805
[2] Patent: US2010/298562, 2010, A1. Location in patent: Page/Page column 34
[3] Organic Letters, 2000, vol. 2, # 6, p. 803 - 805
[4] Phosphorus and Sulfur and the Related Elements, 1987, vol. 34, p. 123 - 132
[5] Patent: CN107935919, 2018, A. Location in patent: Paragraph 0049; 0051

6,6'-Dichloro-2,2'-bipyridine(53344-72-2)Related Product Information

• 6-CHLORO-2,2'-BIPYRIDINE
• 6,6'-Dichloro-2,2'-bipyridine